Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for APEX2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID27301
Official gene symbolAPEX2
Full nameAPEX nuclease (apurinic/apyrimidinic endonuclease) 2
Gene summaryApurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). [provided by RefSeq]
LocationChromosome: X   Locus: 
Gene position55026780 - 55034212  Map Viewer
OMIM ID300773