Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for HLA-DPB1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3115
Official gene symbolHLA-DPB1
Full namemajor histocompatibility complex, class II, DP beta 1
Gene summaryHLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq]
LocationChromosome: 6   Locus: 
Gene position33043760 - 33054976  Map Viewer
OMIM ID142858