Gene information for HNMT (Homo sapiens)
(Information is obtained from NCBI Gene database) |
Entrez gene ID | 3176 |
Official gene symbol | HNMT |
Full name | histamine N-methyltransferase |
Aliases | ,HMT,HNMT-S1,HNMT-S2, |
Gene summary | In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq] |
Location | Chromosome: 2 Locus: |
Gene position | 138721808 - 138773934 Map Viewer |
OMIM ID | 605238 |