Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for IL7R (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID3575
Official gene symbolIL7R
Full nameinterleukin 7 receptor
Gene summaryThe protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq]
LocationChromosome: 5   Locus: 
Gene position35856991 - 35876924  Map Viewer
OMIM ID146661