Gene information for ITGAE (Homo sapiens)
(Information is obtained from NCBI Gene database)
| Entrez gene ID | 3682 |
| Official gene symbol | ITGAE |
| Full name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
| Aliases | ,CD103,HUMINAE,MGC141996, |
| Gene summary | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq] |
| Location | Chromosome: 17 Locus: |
| Gene position | 3704537 - 3617919 Map Viewer |
| OMIM ID | 604682 |
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