|
|||||
| Entrez gene ID | 4041 |
| Official gene symbol | LRP5 |
| Full name | low density lipoprotein receptor-related protein 5 |
| Aliases | ,BMND1,EVR1,EVR4,HBM,LR3,LRP7,OPPG,OPS,OPTA1,VBCH2, |
| Gene summary | This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. [provided by RefSeq] |
| Location | Chromosome: 11 Locus: |
| Gene position | 68080108 - 68216743 Map Viewer |
| OMIM ID | 603506 |