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Entrez gene ID | 51191 |
Official gene symbol | HERC5 |
Full name | hect domain and RLD 5 |
Aliases | ,CEB1,CEBP1, |
Gene summary | This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq] |
Location | Chromosome: 4 Locus: |
Gene position | 89378268 - 89427314 Map Viewer |
OMIM ID | 608242 |