Gene Protein Transcript Blast result Transcript specific probe-cluster
 
Gene information for WWOX (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID51741
Official gene symbolWWOX
Full nameWW domain containing oxidoreductase
Aliases,D16S432E,FOR,FRA16D,HHCMA56,PRO0128,SDR41C1,WOX1,
Gene summaryWW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq]
LocationChromosome: 16   Locus: 
Gene position78133551 - 79246564  Map Viewer