Gene information for PRKAA2 (Homo sapiens)
(Information is obtained from NCBI Gene database) |
Entrez gene ID | 5563 |
Official gene symbol | PRKAA2 |
Full name | protein kinase, AMP-activated, alpha 2 catalytic subunit |
Aliases | ,AMPK,AMPK2,PRKAA, |
Gene summary | The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq] |
Location | Chromosome: 1 Locus: |
Gene position | 57110990 - 57181008 Map Viewer |
OMIM ID | 600497 |