Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for PRKAB1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5564
Official gene symbolPRKAB1
Full nameprotein kinase, AMP-activated, beta 1 non-catalytic subunit
Gene summaryThe protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq]
LocationChromosome: 12   Locus: 
Gene position120105761 - 120119429  Map Viewer
OMIM ID602740