Gene information for PRKAB2 (Homo sapiens)
(Information is obtained from NCBI Gene database) |
Entrez gene ID | 5565 |
Official gene symbol | PRKAB2 |
Full name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | ,MGC61468, |
Gene summary | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [provided by RefSeq] |
Location | Chromosome: 1 Locus: |
Gene position | 146644129 - 146626685 Map Viewer |
OMIM ID | 602741 |