Gene information for VAC14 (Homo sapiens)
(Information is obtained from NCBI Gene database) |
Entrez gene ID | 55697 |
Official gene symbol | VAC14 |
Full name | Vac14 homolog (S. cerevisiae) |
Aliases | ,ArPIKfyve,FLJ10305,FLJ36622,FLJ46582,MGC149815,MGC149816,TAX1BP2,TRX, |
Gene summary | The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM] |
Location | Chromosome: 16 Locus: |
Gene position | 70835061 - 70721342 Map Viewer |
OMIM ID | 604632 |