Gene information for PRKCI (Homo sapiens)
(Information is obtained from NCBI Gene database)
| Entrez gene ID | 5584 |
| Official gene symbol | PRKCI |
| Full name | protein kinase C, iota |
| Aliases | ,DXS1179E,MGC26534,PKCI,nPKC-iota, |
| Gene summary | This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq] |
| Location | Chromosome: 3 Locus: |
| Gene position | 169940220 - 170023770 Map Viewer |
| OMIM ID | 600539 |
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