Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for PCDHA5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID56143
Official gene symbolPCDHA5
Full nameprotocadherin alpha 5
Gene summaryThis gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq]
LocationChromosome: 5   Locus: 
Gene position140201361 - 140391929  Map Viewer
OMIM ID606311