Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for BAI1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID575
Official gene symbolBAI1
Full namebrain-specific angiogenesis inhibitor 1
Gene summaryAngiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq]
LocationChromosome: 8   Locus: 
Gene position143545377 - 143626368  Map Viewer
OMIM ID602682