Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for TLR5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7100
Official gene symbolTLR5
Full nametoll-like receptor 5
Gene summaryThis gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
LocationChromosome: 1   Locus: 
Gene position223316624 - 223282748  Map Viewer
OMIM ID603031