Gene information for TLR5 (Homo sapiens)
(Information is obtained from NCBI Gene database) |
Entrez gene ID | 7100 |
Official gene symbol | TLR5 |
Full name | toll-like receptor 5 |
Aliases | ,FLJ10052,MGC126430,MGC126431,SLEB1,TIL3, |
Gene summary | This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. |
Location | Chromosome: 1 Locus: |
Gene position | 223316624 - 223282748 Map Viewer |
OMIM ID | 603031 |