Gene information for TNFRSF1B (Homo sapiens)
(Information is obtained from NCBI Gene database)
| Entrez gene ID | 7133 |
| Official gene symbol | TNFRSF1B |
| Full name | tumor necrosis factor receptor superfamily, member 1B |
| Aliases | ,CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR, |
| Gene summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq] |
| Location | Chromosome: 1 Locus: |
| Gene position | 12227060 - 12269277 Map Viewer |
| OMIM ID | 191191 |
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