Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for MANF (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7873
Official gene symbolMANF
Full namemesencephalic astrocyte-derived neurotrophic factor
Gene summaryThe protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq]
LocationChromosome: 3   Locus: 
Gene position51422692 - 51426828  Map Viewer
OMIM ID601916