Gene information for MANF (Homo sapiens)
(Information is obtained from NCBI Gene database) |
Entrez gene ID | 7873 |
Official gene symbol | MANF |
Full name | mesencephalic astrocyte-derived neurotrophic factor |
Aliases | ,ARMET,ARP,MGC142148,MGC142150, |
Gene summary | The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq] |
Location | Chromosome: 3 Locus: |
Gene position | 51422692 - 51426828 Map Viewer |
OMIM ID | 601916 |