Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for TOP3B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8940
Official gene symbolTOP3B
Full nametopoisomerase (DNA) III beta
Gene summaryThis gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described. [provided by RefSeq]
LocationChromosome: 22   Locus: 
Gene position22337147 - 22311403  Map Viewer
OMIM ID603582