Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for WASL (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8976
Official gene symbolWASL
Full nameWiskott-Aldrich syndrome-like
Gene summaryThe Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq]
LocationChromosome: 7   Locus: 
Gene position123389116 - 123321997  Map Viewer
OMIM ID605056