Gene Protein Transcript Blast result Transcript specific probe-cluster
Gene information for ACVR2A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID92
Official gene symbolACVR2A
Full nameactivin A receptor, type IIA
Gene summaryThis gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq]
LocationChromosome: 2   Locus: 
Gene position148602570 - 148688393  Map Viewer
OMIM ID102581