Gene information for ABCG2 (Homo sapiens)
(Information is obtained from NCBI Gene database) |
Entrez gene ID | 9429 |
Official gene symbol | ABCG2 |
Full name | ATP-binding cassette, sub-family G (WHITE), member 2 |
Aliases | ,ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,MGC102821,MRX,MXR,MXR1, |
Gene summary | The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq] |
Location | Chromosome: 4 Locus: |
Gene position | 89080011 - 89011416 Map Viewer |
OMIM ID | 603756 |