Search results for the GEO ID: GSE10096  |
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GSM ID | GPL ID |
Select for analysis |
Title |
Source name |
Description |
Characteristics |
GSM254984 | GPL571 |
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Lung cancer metastatic gene signature: control cell lines without luciferase reporter, bio-replicate 1.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Control cell lines without luciferase reporter. Biological replicate 1.
(11-ctrNoLuc)
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GSM254986 | GPL571 |
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Lung cancer metastatic gene signature: control cell lines with luciferase reporter, bio-replicate 1.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Control cell lines with luciferase reporter. Biological replicate 1.
(12-ctrSiLuc)
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GSM254987 | GPL571 |
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Lung cancer metastatic gene signature: control cell lines without luciferase reporter, bio-replicate 2.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Control cell lines without luciferase reporter. Biological replicate 2.
(13-ctrNoLuc)
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GSM254988 | GPL571 |
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Lung cancer metastatic gene signature: control cell lines with luciferase reporter, bio-replicate 2.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Control cell lines with luciferase reporter. Biological replicate 2.
(14-ctrSiLuc)
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GSM254989 | GPL571 |
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Lung cancer metastatic gene signature: metastatic cell line M1, bio-replicate 1.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Human highly metastatic cell line M1. Bio-Replicate 1.
(16-metM1+)
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GSM254991 | GPL571 |
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Lung cancer metastatic gene signature: metastatic cell line M4, bio-replicate 1.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Human highly metastatic cell line M4. Bio-Replicate 1.
(18-metM4+)
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GSM254992 | GPL571 |
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Lung cancer metastatic gene signature: metastatic cell line M5, bio-replicate 1.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Human highly metastatic cell line M5. Bio-Replicate 1.
(21-metM5+)
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GSM254994 | GPL571 |
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Lung cancer metastatic gene signature: metastatic cell line M1, bio-replicate 2.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Human highly metastatic cell line M1. Bio-Replicate 2.
(22-metM1+)
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GSM254995 | GPL571 |
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Lung cancer metastatic gene signature: metastatic cell line M4, bio-replicate 2.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Human highly metastatic cell line M4. Bio-Replicate 2.
(24-metM4+)
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GSM254998 | GPL571 |
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Lung cancer metastatic gene signature: metastatic cell line M1, bio-replicate 3.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Human highly metastatic cell line M1. Bio-Replicate 3.
(26-metM1+)
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GSM254999 | GPL571 |
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Lung cancer metastatic gene signature: metastatic cell line M4, bio-replicate 3.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Human highly metastatic cell line M4. Bio-Replicate 3.
(25-metM4+)
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GSM255661 | GPL571 |
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Lung cancer metastatic gene signature: metastatic cell line M5, bio-replicate 2.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Human highly metastatic cell line M5. Bio-Replicate 2.
(27-metM5+)
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GSM255663 | GPL571 |
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Lung cancer metastatic gene signature: metastatic cell line M5, bio-replicate 3.
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Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC)
|
Human highly metastatic cell lines derived from Non-Small Cell Lung Carcinoma (NSCLC) with specific bone tropism. Cell lines were stably transfected with a luciferase reporter gene. During screening, selected cell lines induced prominent bone metastases lesions in the hind limbs.
Subpopulations of cells with high metastatic ability were isolated using the following strategy: after intracardiac (i.c.) injection of control cells, the subpopulations metastasizing with a high efficiency to bone were isolated and metastatic activity for each one was assessed by i.c. reinoculation of 10 mice per group. With some subpopulations, bone metastases appeared with a latency time ranging from 9-15 days to 20-30 days.
To assess the metastatic activity and to be able to systematically and accurately discriminate the subpopulations with different metastatic activities three complementary parameters were evaluated. First, metastatic activity of the injected control cells and all derived cellular subpopulations was assessed using Kaplan-Meier curves. Compared to the control cell line, several subpopulations named M1, M4 and M5 had an increased metastatic activity by thriving efficiently at bone and decreasing animal survival. Second, 22 days post-inoculation, computerized image analysis revealed an increased bone metastatic area of the hind limbs induced by the more aggressive subpopulations M1, M4 and M5 compared to the control cell lines. And third, 22 days after i.c. inoculation, metastatic cells in the hind limbs were isolated by bone marrow “flushing”. Conspicuous SCCs derived from each animal (10 mice/group) were counted. Subpopulations M1, M4 and M5 induced a more abundant yield of SCCs than control cell lines.
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Human highly metastatic cell line M5. Bio-Replicate 3.
(28-metM5+)
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