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Search results for the GEO ID: GSE13550
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GSM339919
GPL1355
KJ_Dam2_GD20_Testis_Oil testis exposed to oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.01 RNA Integrity Number: 8.7 Bioanalyzer Results: good Sample Preservation: Snap Frozen Pooled from Multiple Samples: Yes Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Gestational Day 20 Sacrifice Method: carbon dioxide Sex: male Age: 20 Units of Age: Gestation Day Genetic Modifications: none Disease State: none KJ_Dam2_GD20_Testis_Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339920
GPL1355
KJ_Dam3_GD20_Testis_Oil testis exposed to oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.00 RNA Integrity Number: 8.8 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Gestational Day 20 Sacrifice Method: carbon dioxide Sex: male Age: 20 Units of Age: Gestation Day Genetic Modifications: none Disease State: none KJ_Dam3_GD20_Testis_Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339921
GPL1355
KJ_Dam16_GD20_Testis_DBP testis exposed to DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 1.96 RNA Integrity Number: 8.7 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Gestational Day 20 Sacrifice Method: carbon dioxide Sex: male Age: 20 Units of Age: Gestation Day Genetic Modifications: none Disease State: none KJ_Dam16_GD20_Testis_DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339922
GPL1355
KJ_Dam18_GD20_Testis_DBP testis exposed to DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 1.95 RNA Integrity Number: 8.8 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Gestational Day 20 Sacrifice Method: carbon dioxide Sex: male Age: 20 Units of Age: Gestation Day Genetic Modifications: none Disease State: none KJ_Dam18_GD20_Testis_DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339923
GPL1355
KJ_Dam19_GD20_Testis_DBP testis exposed to DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 1.99 RNA Integrity Number: 8.6 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Gestational Day 20 Sacrifice Method: carbon dioxide Sex: male Age: 20 Units of Age: Gestation Day Genetic Modifications: none Disease State: none KJ_Dam19_GD20_Testis_DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339924
GPL1355
KJ_Dam21_GD20_Testis_DBP testis exposed to DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.01 RNA Integrity Number: 8.7 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Gestational Day 20 Sacrifice Method: carbon dioxide Sex: male Age: 20 Units of Age: Gestation Day Genetic Modifications: none Disease State: none KJ_Dam21_GD20_Testis_DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339925
GPL1355
KJ_Dam4_GD20_Testis_Oil testis exposed to oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 1.99 RNA Integrity Number: 8.7 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Gestational Day 20 Sacrifice Method: carbon dioxide Sex: male Age: 20 Units of Age: Gestation Day Genetic Modifications: none Disease State: none KJ_Dam4_GD20_Testis_Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339926
GPL1355
KJ_Dam5_GD20_Testis_Oil testis exposed to oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 1.99 RNA Integrity Number: 8.8 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Gestational Day 20 Sacrifice Method: carbon dioxide Sex: male Age: 20 Units of Age: Gestation Day Genetic Modifications: none Disease State: none KJ_Dam5_GD20_Testis_Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339927
GPL1355
KJ_Pup#104_PND35_Testis_Oil-Oil testis exposed to oil-oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.02 RNA Integrity Number: 8.5 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#104_PND35_Testis_Oil-Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339928
GPL1355
KJ_Pup#105_PND35_Testis_Oil-DBP testis exposed to oil-DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.02 RNA Integrity Number: 8.5 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#105_PND35_Testis_Oil-DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339929
GPL1355
KJ_Pup#110_PND35_Testis_Oil-Oil testis exposed to oil-oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.03 RNA Integrity Number: 8.2 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#110_PND35_Testis_Oil-Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339930
GPL1355
KJ_Pup#111_PND35_Testis_Oil-DBP testis exposed to oil-DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.02 RNA Integrity Number: 8.7 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#111_PND35_Testis_Oil-DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339931
GPL1355
KJ_Pup#114_PND35_Testis_Oil-Oil testis exposed to oil-oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.01 RNA Integrity Number: 8.6 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#114_PND35_Testis_Oil-Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339932
GPL1355
KJ_Pup#115_PND35_Testis_Oil-DBP testis exposed to oil-DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.02 RNA Integrity Number: 8.7 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#115_PND35_Testis_Oil-DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339933
GPL1355
KJ_Pup#120_PND35_Testis_Oil-Oil testis exposed to oil-oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 1.98 RNA Integrity Number: 8.4 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#120_PND35_Testis_Oil-Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339934
GPL1355
KJ_Pup#121_PND35_Testis_Oil-DBP testis exposed to oil-DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.04 RNA Integrity Number: 8.5 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#121_PND35_Testis_Oil-DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339935
GPL1355
KJ_Pup#123_PND35_Testis_DBP-Oil testis exposed to DBP-oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.03 RNA Integrity Number: 8.6 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#123_PND35_Testis_DBP-Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339936
GPL1355
KJ_Pup#124_PND35_Testis_DBP-DBP testis exposed to DBP-DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.02 RNA Integrity Number: 8.5 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#124_PND35_Testis_DBP-DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339937
GPL1355
KJ_Pup#127_PND35_Testis_DBP-Oil testis exposed to DBP-oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.03 RNA Integrity Number: 8.8 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#127_PND35_Testis_DBP-Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339938
GPL1355
KJ_Pup#128_PND35_Testis_DBP-DBP testis exposed to DBP-DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.04 RNA Integrity Number: 8.8 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#128_PND35_Testis_DBP-DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339939
GPL1355
KJ_Pup#132_PND35_Testis_DBP-Oil testis exposed to DBP-oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.03 RNA Integrity Number: 8.8 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#132_PND35_Testis_DBP-Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339940
GPL1355
KJ_Pup#133_PND35_Testis_DBP-DBP testis exposed to DBP-DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.04 RNA Integrity Number: 8.9 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#133_PND35_Testis_DBP-DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339941
GPL1355
KJ_Pup#134_PND35_Testis_DBP-Oil testis exposed to DBP-oil Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.02 RNA Integrity Number: 8.9 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#134_PND35_Testis_DBP-Oil_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
GSM339942
GPL1355
KJ_Pup#135_PND35_Testis_DBP-DBP testis exposed to DBP-DBP Sample Type: Tissue, Tissue: none, Tissue Harvest Methods: Tissue was excised from animal, detunicated, and snap frozen prior to RNA isolation. Array Type: Rat230_2 Ratio: 2.00 RNA Integrity Number: 8.8 Bioanalyzer Results: good Sample Preservation: Snap Frozen Strain or Line: Fisher 344 NCBI Taxonomy ID: 10116 Developmental State: Peripubertal Sacrifice Method: carbon dioxide Sex: male Age: 35 Units of Age: Postnatal Day Genetic Modifications: none Disease State: none KJ_Pup#135_PND35_Testis_DBP-DBP_Rat230_2_KJ_CIIT06012: Pregnant Fisher 344 rats will be purchased from Charles River Laboratories, Inc. and delivered to CIIT on gestational day (GD) 7 (GD0 = day first vaginal plug positive). At gestational day 12 (GD12), the dams will be exposed once/day until GD20 to 50 mg/kg dibutyl phthalate (DBP) in corn oil vehicle via oral gavage. Each dose group will contain 4-6 vehicle control or phthalate treated dams. Groups of animals will be sacrificed at GD20, postnatal day (PND) 35, and PND90 for endpoint analysis. At GD20, treated and control animals will be examined for various endpoints including body weight, testicular histopathology, gene expression profile via microarray analysis, and anogenital distance (AGD). AGD (at parturition; PND1) and nipple number/location (at PND14 and day of sacrifice) will be determined on animals in the postnatal groups. At PND35 or 90, one male from each in utero corn oil vehicle or DBP exposed group will receive a second gavage of either corn oil or 500 mg/kg DBP. 6 hours after the second gavage, the following endpoints will be examined: 1) testis histopathology; 2) spermatid head quantification (PND90 only); 3) testis and body weights; 5) genome-wide gene expression (via microarray); and 6) germ cell apoptosis (TUNEL assay).
 
 
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