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Search results for the GEO ID: GSE21583
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GSM538875
GPL1261
Control mouse lung (1) Whole lung homogenate, -ACE2, -BMPR2 strain: FVB/N gender: female tissue: whole lung genotype: heterozygous for Rosa26-rtTA2 transgene treatment: none Pooled RNA from whole lung homogenate from three female FVB/N mouse heterozygous for Rosa26-rtTA2 transgene, fed doxycycline for 6 weeks starting at average age 5 months. Mice had near normal right ventricular systolic pressure (RVSP) at time of sacrifice. The Rosa26-rtTA2 transgene drives universal expression of a transactivator, which has no phenotype in the absence of other transgenes - this is thus a control group.
GSM538876
GPL1261
Control mouse lung (2) Whole lung homogenate, -ACE2, -BMPR2 strain: FVB/N gender: female tissue: whole lung genotype: heterozygous for Rosa26-rtTA2 transgene treatment: none Pooled RNA from whole lung homogenate from three female FVB/N mouse heterozygous for Rosa26-rtTA2 transgene, fed doxycycline for 6 weeks starting at average age 5 months. Mice had near normal right ventricular systolic pressure (RVSP) at time of sacrifice. The Rosa26-rtTA2 transgene drives universal expression of a transactivator, which has no phenotype in the absence of other transgenes - this is thus a control group.
GSM538877
GPL1261
Control mouse + chronic ACE2 lung (1) Whole lung homogenate, +ACE2, -BMPR2 strain: FVB/N gender: female tissue: whole lung genotype: heterozygous for Rosa26-rtTA2 transgene treatment: ACE2 Pooled RNA from whole lung homogenate from three female FVB/N mouse heterozygous for Rosa26-rtTA2 transgene, fed doxycycline for 6 weeks starting at average age 5 months, with recombinant human ACE2 in osmotic pumps infused for the final 2 weeks. Mice had near normal right ventricular systolic pressure (RVSP) at time of sacrifice.
GSM538878
GPL1261
Control mouse + chronic ACE2 lung (2) Whole lung homogenate, +ACE2, -BMPR2 strain: FVB/N gender: female tissue: whole lung genotype: heterozygous for Rosa26-rtTA2 transgene treatment: ACE2 Pooled RNA from whole lung homogenate from three female FVB/N mouse heterozygous for Rosa26-rtTA2 transgene, fed doxycycline for 6 weeks starting at average age 5 months, with recombinant human ACE2 in osmotic pumps infused for the final 2 weeks. Mice had near normal right ventricular systolic pressure (RVSP) at time of sacrifice.
GSM538879
GPL1261
Rosa26-BMPR2-R899X mouse + chronic ACE2 lung (1) Whole lung homogenate, +ACE2, +BMPR2 strain: FVB/N gender: female tissue: whole lung genotype: heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes treatment: ACE2 Pooled RNA from whole lung homogenate from three female FVB/N mouse heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes, fed doxycycline for 6 weeks starting at average age 5 months, with recombinant human ACE2 in osmotic pumps infused for the final 2 weeks. Mice had near normal right ventricular systolic pressure (RVSP) at time of sacrifice. These transgenics often develop pulmonary arterial hypertension.
GSM538880
GPL1261
Rosa26-BMPR2-R899X mouse + chronic ACE2 lung (2) Whole lung homogenate, +ACE2, +BMPR2 strain: FVB/N gender: female tissue: whole lung genotype: heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes treatment: ACE2 Pooled RNA from whole lung homogenate from three female FVB/N mouse heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes, fed doxycycline for 6 weeks starting at average age 5 months, with recombinant human ACE2 in osmotic pumps infused for the final 2 weeks. Mice had near normal right ventricular systolic pressure (RVSP) at time of sacrifice. These transgenics often develop pulmonary arterial hypertension.
GSM538881
GPL1261
Rosa26-BMPR2-R899X lung (1) Whole lung homogenate, -ACE2, +BMPR2 strain: FVB/N gender: female tissue: whole lung genotype: heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes treatment: none Pooled RNA from whole lung homogenate from three female FVB/N mouse heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes, fed doxycycline for 6 weeks starting at average age 5 months, with vehicle control in osmotic pumps infused for the final 2 weeks. Mice had near normal right ventricular systolic pressure (RVSP) at time of sacrifice. These transgenics often develop pulmonary arterial hypertension.
GSM538882
GPL1261
Rosa26-BMPR2-R899X lung (2) Whole lung homogenate, -ACE2, +BMPR2 strain: FVB/N gender: female tissue: whole lung genotype: heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes treatment: none Pooled RNA from whole lung homogenate from three female FVB/N mouse heterozygous for Rosa26-rtTA2 and TetO7-Bmpr2-R899X transgenes, fed doxycycline for 6 weeks starting at average age 5 months, with vehicle control in osmotic pumps infused for the final 2 weeks. Mice had near normal right ventricular systolic pressure (RVSP) at time of sacrifice. These transgenics often develop pulmonary arterial hypertension.
 
 
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