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Search results for the GEO ID: GSE21982
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GPL ID
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Description
Characteristics
GSM546579
GPL571
t469ns_1 t469ns_1 genotype: mutant hek_t469 harvest date: 23-12-09 treatment: no treatment cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546580
GPL571
t466nsbis_1 t466nsbis_1 genotype: mutant hek293_t466 harvest date: 20-10-09 treatment: no treatment cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546581
GPL571
t466nsbis_2 t466nsbis_2 genotype: mutant hek293_t466 harvest date: 20-10-09 treatment: no treatment cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546582
GPL571
t469fsh_3 t469fsh_3 genotype: mutant hek_t469 harvest date: 23-12-09 treatment: FSH - hormone treatment - fsh stimulation concentration: 3nM time: 6 hours cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546583
GPL571
wtfsh_1 wtfsh_1 genotype: wild type harvest date: 20-10-09 treatment: FSH - hormone treatment - fsh stimulation concentration: 3nM time: 6 hours cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546584
GPL571
t466fsh_3 t466fsh_3 genotype: mutant hek293_t466 harvest date: 20-10-09 treatment: FSH - hormone treatment - fsh stimulation concentration: 3nM time: 6 hours cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546585
GPL571
t469ns_3 t469ns_3 genotype: mutant hek_t469 harvest date: 23-12-09 treatment: no treatment cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546586
GPL571
wtns_1 wtns_1 genotype: wild type harvest date: 20-10-09 treatment: no treatment cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546587
GPL571
t469fsh_1 t469fsh_1 genotype: mutant hek_t469 harvest date: 23-12-09 treatment: FSH - hormone treatment - fsh stimulation concentration: 3nM time: 6 hours cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546588
GPL571
t469fsh_2 t469fsh_2 genotype: mutant hek_t469 harvest date: 23-12-09 treatment: FSH - hormone treatment - fsh stimulation concentration: 3nM time: 6 hours cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546589
GPL571
t466fsh_1 t466fsh_1 genotype: mutant hek293_t466 harvest date: 20-10-09 treatment: FSH - hormone treatment - fsh stimulation concentration: 3nM time: 6 hours cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546590
GPL571
wtfsh_3 wtfsh_3 genotype: wild type harvest date: 20-10-09 treatment: FSH - hormone treatment - fsh stimulation concentration: 3nM time: 6 hours cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546591
GPL571
t466fsh_2 t466fsh_2 genotype: mutant hek293_t466 harvest date: 20-10-09 treatment: FSH - hormone treatment - fsh stimulation concentration: 3nM time: 6 hours cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546592
GPL571
wtfsh_2 wtfsh_2 genotype: wild type harvest date: 20-10-09 treatment: FSH - hormone treatment - fsh stimulation concentration: 3nM time: 6 hours cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546593
GPL571
t469ns_2 t469ns_2 genotype: mutant hek_t469 harvest date: 23-12-09 treatment: no treatment cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546594
GPL571
wtns_2 wtns_2 genotype: wild type harvest date: 20-10-09 treatment: no treatment cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546595
GPL571
wtns_3 wtns_3 genotype: wild type harvest date: 20-10-09 treatment: no treatment cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
GSM546596
GPL571
t466nsbis_3 t466nsbis_3 genotype: mutant hek293_t466 harvest date: 20-10-09 treatment: no treatment cell line: HEK-293 - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered -arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit -arrestins and signal through them.
 
 
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