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Search results for the GEO ID: GSE6078
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GSM140792
GPL1261
Control_1_intestine_30days Control small intestine 1, polyI:C, 30 days Strain: Mixed genetic background, predominantly (>87.5%) C56BL/6 with some CD1. Genotype: Mx1-Cre negative: PTENfx/+. Sex: Female Age: eight and a half weeks (at tissue isolation). Tissue: Small Intestine (jejunum/ileum region). The study examines the effect of conditional PTEN deletion in the small intestine. Deletion of the PTEN exon 5 (encoding the phosphatase motif) was accomplished using the interferon-inducible Mx1-Cre, induced by five injections of polyinosinic-polycytidylic acid. The experiment compared the gene expression profiles of polyp regions from three PTEN mutant animals with intestines from two control animals. Genes were considered up-regulated or down-regulated if all of the following conditions were met: 1) There was at least a two-fold change in the average values measured between controls and mutants; 2) There was no overlap between the range of mutant and control data; and 3) The control mean was outside the 95% confidence interval of the PTEN-mutant mean.
GSM140813
GPL1261
PTEN_mutant_1_intestinal_polyp_30days PTEN mutant 1 intestinal polyp, 30 days post polyI:C Mx1-Cre positive: PTENfx/fx. Sex: Male. Age: Eight and a half weeks (at tissue isolation). Tissue: Intestinal Polyp (from jejunun/ileum). The study examines the effect of conditional PTEN deletion in the small intestine. Deletion of the PTEN exon 5 (encoding the phosphatase motif) was accomplished using the interferon-inducible Mx1-Cre, induced by five injections of polyinosinic-polycytidylic acid. The experiment compared the gene expression profiles of polyp regions from three PTEN mutant animals with intestines from two control animals. Genes were considered up-regulated or down-regulated if all of the following conditions were met: 1) There was at least a two-fold change in the average values measured between controls and mutants; 2) There was no overlap between the range of mutant and control data; and 3) The control mean was outside the 95% confidence interval of the PTEN-mutant mean.
GSM140816
GPL1261
Control_2_intestine_30days Control 2 small intestine, 30 days Strain: mixed genetic background, predominantly (>87.5%) C57BL/6 with some CD1. Genotype: Mx1-Cre negative: PTENfx/+. Sex: Female. Age: Eight and a half weeks (at tissue isolation). Tissue: small intestine (jejunum/ileum). The study examines the effect of conditional PTEN deletion in the small intestine. Deletion of the PTEN exon 5 (encoding the phosphatase motif) was accomplished using the interferon-inducible Mx1-Cre, induced by five injections of polyinosinic-polycytidylic acid. The experiment compared the gene expression profiles of polyp regions from three PTEN mutant animals with intestines from two control animals. Genes were considered up-regulated or down-regulated if all of the following conditions were met: 1) There was at least a two-fold change in the average values measured between controls and mutants; 2) There was no overlap between the range of mutant and control data; and 3) The control mean was outside the 95% confidence interval of the PTEN-mutant mean.
GSM140817
GPL1261
PTEN_mutant_2_intestinal_polyp_30days PTEN mutant 2 intestinal polyp, polyI:C, 30 days Mx1-Cre positive: PTENfx/fx. Sex: Female. Age: Eight and a half weeks (at tissue isolation). Tissue: Intestinal polyp from small intestine (jejunum/ileum region). The study examines the effect of conditional PTEN deletion in the small intestine. Deletion of the PTEN exon 5 (encoding the phosphatase motif) was accomplished using the interferon-inducible Mx1-Cre, induced by five injections of polyinosinic-polycytidylic acid. The experiment compared the gene expression profiles of polyp regions from three PTEN mutant animals with intestines from two control animals. Genes were considered up-regulated or down-regulated if all of the following conditions were met: 1) There was at least a two-fold change in the average values measured between controls and mutants; 2) There was no overlap between the range of mutant and control data; and 3) The control mean was outside the 95% confidence interval of the PTEN-mutant mean.
GSM140818
GPL1261
PTEN_mutant_3_intestinal_polyp_30_days PTEN mutant 3 intestinal polyp, polyI:C, 30 days Mx1-Cre positive: PTENfx/fx. Sex: Female. Age: Eight and a half weeks (at tissue isolation). Tissue: Intestinal polyp from small intestine (jejunum/ileum region). The study examines the effect of conditional PTEN deletion in the small intestine. Deletion of the PTEN exon 5 (encoding the phosphatase motif) was accomplished using the interferon-inducible Mx1-Cre, induced by five injections of polyinosinic-polycytidylic acid. The experiment compared the gene expression profiles of polyp regions from three PTEN mutant animals with intestines from two control animals. Genes were considered up-regulated or down-regulated if all of the following conditions were met: 1) There was at least a two-fold change in the average values measured between controls and mutants; 2) There was no overlap between the range of mutant and control data; and 3) The control mean was outside the 95% confidence interval of the PTEN-mutant mean.
 
 
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