Entrez gene ID | | 6868 |
Official gene symbol | | ADAM17 |
Full name | | ADAM metallopeptidase domain 17 |
Aliases | | ,ADAM18,CD156B,CSVP,MGC71942,TACE, |
Gene summary | | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2p25 |
Gene position | | 9695917 - 9629392 Map Viewer |
Gene orientation | | minus |
Gene size | | 66526 bp |
Gene sequence |
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OMIM ID | | 603639 |
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