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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ADAM17 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001666 response to hypoxia IDA GO:0001934 positive regulation of protein phosphorylation IMP GO:0002446 neutrophil mediated immunity IC GO:0002467 germinal center formation ISS GO:0002690 positive regulation of leukocyte chemotaxis IC GO:0006508 proteolysis IEA GO:0006509 membrane protein ectodomain proteolysis IDA GO:0006509 membrane protein ectodomain proteolysis IMP GO:0006916 anti-apoptosis IEA GO:0007155 cell adhesion IDA GO:0007173 epidermal growth factor receptor signaling pathway IDA GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007219 Notch signaling pathway IEA GO:0008284 positive regulation of cell proliferation IMP GO:0010820 positive regulation of T cell chemotaxis IMP GO:0030183 B cell differentiation ISS GO:0030307 positive regulation of cell growth IMP GO:0030335 positive regulation of cell migration IMP GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway ISS GO:0031293 membrane protein intracellular domain proteolysis TAS GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S IDA GO:0032496 response to lipopolysaccharide IDA GO:0032717 negative regulation of interleukin-8 production IMP GO:0032722 positive regulation of chemokine production IMP GO:0033025 regulation of mast cell apoptosis ISS GO:0033077 T cell differentiation in thymus ISS GO:0033627 cell adhesion mediated by integrin IDA GO:0035313 wound healing, spreading of epidermal cells IEP GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway IMP GO:0042493 response to drug ISS GO:0045741 positive regulation of epidermal growth factor-activated receptor activity IDA GO:0045741 positive regulation of epidermal growth factor-activated receptor activity IMP GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048536 spleen development ISS GO:0048870 cell motility ISS GO:0051088 PMA-inducible membrane protein ectodomain proteolysis IDA GO:0051088 PMA-inducible membrane protein ectodomain proteolysis IMP GO:0051272 positive regulation of cellular component movement ISS GO:0055099 response to high density lipoprotein particle stimulus IDA cellular_component GO:0005737 cytoplasm IDA GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane IDA GO:0005911 cell-cell junction IDA GO:0005925 focal adhesion IDA GO:0009986 cell surface IDA GO:0015629 actin cytoskeleton IDA GO:0016324 apical plasma membrane IDA GO:0032587 ruffle membrane IDA GO:0045121 membrane raft IDA molecular_function GO:0004222 metalloendopeptidase activity IDA GO:0004222 metalloendopeptidase activity IEA GO:0004222 metalloendopeptidase activity IMP GO:0005138 interleukin-6 receptor binding IPI GO:0005178 integrin binding IPI GO:0005515 protein binding IPI GO:0008233 peptidase activity IEA GO:0008237 metallopeptidase activity IDA GO:0008237 metallopeptidase activity IMP GO:0008237 metallopeptidase activity TAS GO:0008270 zinc ion binding IEA GO:0017124 SH3 domain binding IEA GO:0030165 PDZ domain binding IPI GO:0046872 metal ion binding IEA

Protein-protein interaction details for ADAM17 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID DLG1 Two-hybrid physical 12668732 DLG1 Reconstituted Complex physical 12668732 DLG1 Affinity Capture-Western physical 12668732 MAPK1 Reconstituted Complex physical 12058067 MAPK1 Biochemical Activity physical 12058067 MAPK1 Affinity Capture-Western physical 12058067 MAD2L1 Two-hybrid physical 10527948 MAD2L1 Reconstituted Complex physical 10527948 MAD2L1 Affinity Capture-Western physical 10527948 TIMP3 Reconstituted Complex physical 12044879 MAD2L1 Affinity Capture-Western physical 11741929