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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ZBTB33 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 10009 Official gene symbol ZBTB33 Full name zinc finger and BTB domain containing 33 Aliases ,ZNF-kaiso,ZNF348, Gene summary This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified. Location Chromosome: X   Locus: Xq23 Gene position 119384607 - 119392251  Map Viewer Gene orientation plus Gene size 7645 bp Gene sequence >ZBTB33:3652317..3659961:Length=7645 GCCTTTGGCTTCAGCGCTTCGCCCCCGCGCTGTGCCCTCTGTCGGCGGCGTGGGGCAGCT GTAGCAGCGTTGGCGGCAGGAGGCGGCGGCCGCGTCGACGTCGACCCAGACTGGAGCGAC GTTTAAAGAAGGGGCAGAATCGCTGGGGAGTGCGGCTTCTTCTTGTTGGGGGACTCCCAG CCTTCCGCGCGTCCGGAGGAGGAGAAGCGGCGGCGCCGGGAAGCAGGTGAGGACCCGGCC CCAATCAGGGAGGGGGCGAAGGAGCGCGCTTGCCTTCTCCGTCCCTGGGCCGCGCCTGCG TTTGCATTCGCCTCACTTGAACCAGGAAGCGGCAGAGTCGGAGGCTCAGCTCCTCCGGCT CTTTCTTTGTGTGGGCCGGGGAGCGAAGGAGGGGACGAGCCGCGAGGGCCGCGGCGCGGT CCCCTTCGCCGTTAGGGGCCGAGGGGCTGCCGGTGCCCTGGGTAGGCCCCGGGGCTTGGG GAATCCATCACAGAGACCCACTTGGCTTTTCCCTCGCCCCTCTCGCTGCTTTTTTGTGCC TCTTTTACTCCCCTAGCCCCTACTTTGATTTAGAGCTTTTCTGCCAGGCCCATCCTCCCC TTCCGTCCCCTTCCCGGGGCACAACAATGCCGCCTGCTTCGCTTCATCCCCCCCCCAACA CCCCACCCTGCCGTTCGCCACCTTCTACTTTCCCTGGTACCCCATATTCCTCCCGCCCTC ACTCTGCTGTTTGTACCTCCGTCTGTATTTGCAAGAAGCTTGCTTTGCACGTGAATTGGG GTTAAAAACCTCGGTTGCAGCTGGCAGGGTCCATATGGGGAAGAGGGAGGTGGAGGAAGG GAGATGAGGTTCAGCTGCCGCAGGGAGCCGCGTGTCGGTTTGTTTCACTCCCTCGCGGAT GGCTTTTATCTCTTTCCACCGTCACCAGCTCCTCCGAACTGGCCCTCGGTCAAGGGTTTC ACAGTGATGTGGAATGGCTTTTCCACAGTCGAATCGCATATCTTCGGAGTGGGTTCAGAC CGACTTGTGCTGTCTCTGGGGCCACCCTGAGTGGGAGGAGGGGGACACATAAACGAAACG AAACCGAGTCCCAGTGTCACCTGGACACGTACATTTGACGCATTCCCATATTGGAAGAAC CCGGGAGCAAATGACAAAAATTGCGTGCCGTTTTCAGAAAACCTGTCTTTCCACTTAATA TCGACTTCTGTCGAAATGCCCGTATTTCGGAAGCCCTGGTTTTTGGCAAACTGTCCAAAG GTCACCCTTTCTGATGATGAATGCCTTTATGGTAACCTGGAATTCCTTGGTACTGTTAAC ATGCAACACCTTCTAATAATGTTTTAAATCTTGATTTTTAGACTTTTTGCCTGCTGTTTG TTCTTAAGGTATCATTTTGAAAAATTTAGAAGGTATTTGAGACAGAACTGCCCTCCACCT GTATATAACTTAAGCATTGTGACATCGACACCCTTTTGGTAACTTCAAAGGGAGAGAATA TTAATAAAAATATTTCTTCACTAAAAGTACTTGTCAACTAATTGTTAATATATAATATCC ATATATTAAAATATATCCATATATAATATGTATGGATATTATATATTTTTAATATATGGG TTTTTTTAAACTCTGGCCTCTTTGTTACTGGAAATATCTTCTGCAAAGTGCAAAAAATGA TGTTTTGCTAGTGCTACACAACAATGCATTCTACTGACATCATCCCCTTTTTCTAGAGTA GTCTATTCCAATAAGTTAATGTTTTCATTTTCACTAACTCATTTGGTGTGGAAAAAATTC TCATACCAATGCATATGATTCTTTACCAACAAAAATAAAATGTTTCGTGTTTTCTTGGAA GTGGGCATTTAGAAATGGTAAACTTTCCTTTTCCTTTGTCATATTTTTTCATGATAGTGT CTGTTGACTTCACTTGGCACTGTTTAACATTCCACCTCTGGAAATTGTAAAGATGGAGAG ATGAGGGGAAGGGACAAGGGGATGAAGAAAGAGGAAAGGGTAAGAAAGATGTTTAATAGT TTATCAAGATGAGGCACCCCAATTTAAATAACAGAAAAATAATGGGACGTTGGGAGGTAA TAATTGTCAGTGTTTATAAATGTCATTGGCTCCAGGGTGTAGATTCTGCATATATTCTTA AAGATTAGTTAAAATTAAGAGTATGTATTTCAGACACAGTATTGCACGCGCTGAGCTTTT CTGACATTTCAATCATTTACAGGCGAAATAACTTCTGTGTGTTCATGATGATTTTCCTTA ATTTTGACAGTTAAAAGTCAACTCTTACCTCTTCTTGGAGAGAAAACCCAAAATTGGGAC TAAGAAAATTAATTCTAATCTTTAAAAATCACTTAGTGGAGGTGCATGTATCTAATATTC AAAAAAAGGTGACTATGGAGATTACTGTTCAAATCTCTGTAACAATGTAAAACTTGCTCA ACTCAGGAGCAAGCCATGAAATTGGACACTTGTTCCAAAAGCCAACCTGTATGAACAATT TCTGTAAAAGCCAAAAAATTATGCTGAACTTTGGTTAAAACTTGAATAAACTATTTAATG ATGCTACTGCTTAAATTCTAAATAAGTACTTTTGTTTTTTCTCTCTAATCCTCTCCCATC CCCTCCTCTCTTTCTCTTAAAGGCATGGAGAGTAGAAAACTGATTTCTGCTACAGACATT CAGTACTCTGGCAGTCTGCTGAACTCCTTGAATGAGCAACGTGGCCATGGACTCTTCTGT GATGTTACCGTTATTGTGGAAGACCGAAAATTCCGGGCTCACAAGAATATTCTTTCAGCT TCTAGTACCTACTTCCATCAGCTCTTCTCTGTTGCTGGGCAAGTTGTTGAACTGAGCTTT ATAAGAGCAGAGATCTTTGCAGAAATTCTCAATTATATCTATAGTTCTAAAATTGTTCGT GTTAGATCAGATTTGCTTGATGAGTTAATTAAATCAGGGCAGTTATTAGGAGTGAAATTT ATAGCAGAGCTTGGTGTCCCATTGTCACAGGTTAAAAGCATCTCAGGTACAGCGCAGGAT GGTAATACTGAGCCTTTACCTCCTGATTCTGGTGACAAGAACCTTGTAATACAGAAATCA AAAGATGAAGCCCAAGATAATGGGGCTACTATAATGCCTATTATAACAGAGTCTTTTTCA TTATCTGCCGAAGATTATGAAATGAAAAAGATCATTGTTACCGATTCTGATGATGATGAT GATGATGTCATTTTTTGCTCCGAGATTCTGCCCACAAAGGAGACTTTGCCGAGTAATAAC ACAGTGGCACAGGTCCAATCTAACCCAGGCCCTGTTGCTATTTCAGATGTTGCACCTAGT GCTAGCAATAACTCGCCCCCTTTAACAAATATCACACCTACTCAGAAACTTCCTACTCCT GTGAATCAGGCAACTTTGAGCCAAACACAAGGAAGTGAAAAATTGTTGGTATCTTCAGCT CCAACACATCTGACTCCCAATATTATTTTGTTAAATCAGACACCACTTTCTACACCACCA AATGTCAGTTCTTCACTTCCAAATCATATGCCCTCTTCAATCAATTTACTTGTGCAGAAT CAGCAGACACCAAACAGTGCTATTTTAACAGGAAACAAGGCCAATGAAGAGGAGGAGGAG GAAATAATAGATGATGATGATGACACTATTAGCTCCAGTCCTGACTCGGCCGTCAGTAAT ACATCTTTGGTCCCACAGGCTGATACCTCCCAAAATACCAGTTTTGATGGATCATTAATA CAGAAGATGCAGATTCCTACACTTCTTCAAGAACCACTTTCCAATTCCTTAAAAATTTCA GATATAATTACTAGAAATACTAATGATCCAGGCGTAGGATCAAAACATCTAATGGAGGGT CAGAAGATCATTACTTTAGATACAGCTACTGAAATTGAAGGCTTATCGACTGGTTGCAAG GTTTATGCAAATATCGGTGAAGATACTTATGATATAGTGATCCCTGTCAAAGATGACCCT GATGAAGGGGAGGCCAGACTTGAGAATGAAATACCAAAAACGTCTGGCAGCGAGATGGCA AACAAACGTATGAAAGTAAAACATGATGATCACTATGAGTTAATAGTAGATGGAAGGGTC TATTATATCTGTATTGTATGCAAAAGGTCATATGTCTGTCTGACAAGCTTGCGGAGACAT TTTAACATTCATTCTTGGGAGAAGAAGTATCCGTGCCGTTACTGTGAGAAGGTATTTCCT CTTGCAGAATATCGCACAAAGCATGAAATTCATCACACAGGGGAGCGAAGGTATCAGTGT TTGGCCTGTGGCAAATCTTTCATCAACTATCAGTTTATGTCTTCACATATAAAGTCAGTT CATAGTCAAGATCCTTCTGGGGACTCAAAGCTTTATCGTTTACATCCATGCAGGTCTTTA CAAATCAGACAATATGCATATCTTTCCGATAGATCAAGCACTATTCCTGCAATGAAGGAT GATGGTATTGGGTATAAGGTTGACACTGGAAAAGAACCTCCAGTAGGGACCACTACATCT ACTCAGAACAAGCCAATGACCTGGGAAGATATTTTTATTCAGCAGGAAAATGATTCAATT TTTAAACAAAATGTAACAGATGGCAGTACTGAGTTTGAATTTATAATACCAGAGTCTTAC TAAACTCCTTTGAAATACTAGAAAGTTTTGTTTTGGATGATGGGGCAGGGGTTTCAGAAG ATCTGTAAAACAAATTAAGGTGCGAACAAGTTAATTTGATCTGCCACATTATCTGAAGGA AGTGTAGTGGGATTTTTGTTGATAATTTTTAGAAGCAAATTTTCCTGAAAGTTTTGAGTA GAGGTGAGACCCCCTCCCCAAGTATCTGTTTATATAGTTAGTTTTCAGCTCATTTAAAAG AGGCAAAAATTAAAAGCTTGGAGAGATAGTTTCCTGAATAGAATTTGAAGCAGTCTGAAT GTTCTTTGAAAATAACTGGAGTTATTAGCATACCCTAGTACATCTTACAGCTTTCCCCTT CCATGTTAGCACTTTACTGCTGAATTCTCAATTTTCTTAACATTGAGACAATAAATGTGT GTTTTGTCTTGTATATGGCATAAAGAGTAAATAAGTTTTAGAGTTGTTCTGGAAAATGTC AGAATAAGTCAGTACTTGGGTTGTGTAATCTGCTAGTCCAAGCGAACAGCAACCTCCTGC TACCCTCCCTCTATGAAAATAGCCATGCAGACAAGTCTCTCATCTGAAGAACAAATTAGA TTTAGCTAATTAGAATTAATCCTGGCTTTCATTGCCATAGTCTGTAAAAGACTTTGGTGG CTAGACCACTTTATACCTTCGCAGTGTGGTCTCTGGGGGCAAAAAACTAATGAAAACAAT CTCTGTAATGGCAGATAGGAGGAGATGAAAAGTTCTGTTGCATGGATTTTTAATTCTCTG GCTACCACATAGTAGAGAATGGAATGAAGATTTCCTTTTGGCTTCTTAAGGTTAAAAATA TTCCCATGAACATGAAAATTTTCAAATTTTGAATCTGAAAGCCACCAAATGTATCTTTAT GTATAAATCCTTGTAAATGATAGATTCCATGGGTGAGACTTTACATATTTTGGGTGGGAG GCTACTGGCATATATTTTTAAATGTTCATATTGCGTAGAATCTCCACTAGGAAGTCTTTA TTTGAAATAGTTGAATCAGTGATCTAGTATTTTCCTTTCGGCAAGATTTGTTAGGTTTTT ACCCCTTCTAAAATAAGTTTTATTCCATCTGCAAATTGCTGCAATATTATAGTAATCAGA AACTACATAAGGAATGTTATATAGGCTTGTCAGTTCCCATTTTTCTTGACAACAATAAAT ACCACTTTTAAAAATGACACATATTTAAACACTTAGAAAATAAAGTTAACACTTACTGAA GTGCTAGTACTAAACTGTGCTAGTACTAAAAGAAAACAGGTTGGAACATACATATAGCCT AGCATTTATAACAGAATTGTTGAACGTCTGTAAATGATTTTTTTTTTTTTTGCAAAGGAA AAAATTGATACTGGAAAAGATTGTTGTGCATAGTTATTAGTCATTTGTAACCTTGCTTAA GTATTTCTTAGTCCAACATAGATATTTTCTTTCTCCTGACCATGTATTTTAAAATATAGT CTATTTCTTGACTTTGAACTTAAAGCTTTAATCATAATTTCTCATGTATACATCGTTCTT CTGATGGTAAGCTGGATTTGAAGGTAGTGGTTTCAGTGTTTCTTAAGTTGGTAGCTGAGG GTATCAGGCATCAGTTCATGCAATAATACAAGAAAAAAAATCCTTTGCTTGCCAAGAGGT AGAGTGATGTGCATTTATCTGTTTTCTGTTCTGTAAGTCTAGACCTTCAAACCATTTGTA AACTAACCCCTGGGAAATTTGAAATTACCTGATAACTTAAGACTCTGTGATCTCTGGAAT CACCATATGTTTCTTTTTTGTGTAGATATTAATAACATTACTCTTTGACTATAGTGTGCA CTCTGAAATGTACTCAGTGAAAATTTGTTTTGAGTTTCATTAATGCTATTTCACCAGTTA GACATAATTACTTCTACCGATGTGAATGATACGGATGCCGGCAGAGCTTCCAGATCTTTC AGACTCAACTGCTAGGTCAATTAGTTTGTCATAATAAAACTTGGCAGATTCTACAAGTCT ATTATGACAAACCAGGAACTAATTCTATAATGGAAAACTATCCATTCTGAATAATAGGTA TGTAATTATTTGCTGCTGCTGCTGTGCTCTGTAAATTCTGAATATGACATTTAAACTCTG TGCCTACTAAAGGTATCTTCTGGAGTTTTTGGGAGGAGAGAAACTGGAAAATTAAATTGT ATTTTTGCCAGAAGACTCTTACTTGCATGTGTCTCAGGGTCTTCAGTTTTTCTATAAGTT TCCATATCCAAAGTTCAGAATTCATGTGAAATACTTCTTTGGGGCAAAAGTCCTTCATTC CTGGTATTTATTGGATTGGAAATCTGTAGCAAGATGCTGTTTAAAATTACCATATTGTTT TTTTATCTTATACTTAGCTCTCTGGCTATTGAACTTCCTTTTCTTGTTTGAAGTTAGCTT CAAATTTGCTCCTATGCTAAATTACCTGTAAATATTCTGGATAGGAACTACTTGAAATAG TAATTTGTTAAAAGATATGACAAAATGAAAATGCTTAAACTACAGAAATTTAAAAATGCC ATAACAATCTTGCGAGACTAACTTTAAAATATACTTTAAATGATTATTATGATTTTGGTG GTAACGATCCCCCACACACAACCACTATGAAGAAATAATGCCGCATTTTTCCCCCATTGT ACCAAAAAGATAAAAAAATGGTAAACACTGATCAAGGTATTTTGTATTGTCAAGGCATGC ATATTCTAAAGAATTAAATGCTAACTTAACAGCACTGGCTTTCTGGCTGGTCAACTATAT GAAACCTTGTTCATTCCTCCGAGTACTGTAATGTTCACACTTGTACAATCTTCCCTGTCA TGACTTTAAGTTCTACTTTTCATTAACCATGGCCTGATATTAGTTCTTAGAGCTTCTTGT GGCAAAAATAAAATGATTTAATTCT OMIM ID 300329