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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TANK (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10010
Official gene symbolTANK
Full nameTRAF family member-associated NFKB activator
Aliases,I-TRAF,TRAF2,
Gene summaryThe TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q24-q31
Gene position161993466 - 162092682  Map Viewer
Gene orientationplus
Gene size99217 bp
Gene sequence
OMIM ID603893