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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HDAC5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10014
Official gene symbolHDAC5
Full namehistone deacetylase 5
Aliases,FLJ90614,HD5,NY-CO-9,
Gene summaryHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q21
Gene position42201014 - 42154121  Map Viewer
Gene orientationminus
Gene size46894 bp
Gene sequence
OMIM ID605315