Entrez gene ID | | 10014 |
Official gene symbol | | HDAC5 |
Full name | | histone deacetylase 5 |
Aliases | | ,FLJ90614,HD5,NY-CO-9, |
Gene summary | | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q21 |
Gene position | | 42201014 - 42154121 Map Viewer |
Gene orientation | | minus |
Gene size | | 46894 bp |
Gene sequence |
| |
OMIM ID | | 605315 |
|