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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for BCL2L11 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10018
Official gene symbolBCL2L11
Full nameBCL2-like 11 (apoptosis facilitator)
Aliases,BAM,BIM,BIM-alpha6,BIM-beta6,BIM-beta7,BOD,BimEL,BimL,
Gene summaryThe protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q13
Gene position111878491 - 111926022  Map Viewer
Gene orientationplus
Gene size47532 bp
Gene sequence
OMIM ID603827