Entrez gene ID | | 10038 |
Official gene symbol | | PARP2 |
Full name | | poly (ADP-ribose) polymerase 2 |
Aliases | | ,ADPRT2,ADPRTL2,ADPRTL3,PARP-2,pADPRT-2, |
Gene summary | | This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q11.2-q12 |
Gene position | | 20811773 - 20826063 Map Viewer |
Gene orientation | | plus |
Gene size | | 14291 bp |
Gene sequence |
| |
OMIM ID | | 607725 |