Entrez gene ID | | 1006 |
Official gene symbol | | CDH8 |
Full name | | cadherin 8, type 2 |
Aliases | | ,Nbla04261, |
Gene summary | | This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16q22.1 |
Gene position | | 62070036 - 61687235 Map Viewer |
Gene orientation | | minus |
Gene size | | 382802 bp |
Gene sequence |
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OMIM ID | | 603008 |
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