Entrez gene ID | | 1008 |
Official gene symbol | | CDH10 |
Full name | | cadherin 10, type 2 (T2-cadherin) |
Aliases | | ,-, |
Gene summary | | This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5p14-p13 |
Gene position | | 24645085 - 24487209 Map Viewer |
Gene orientation | | minus |
Gene size | | 157877 bp |
Gene sequence |
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