Entrez gene ID | | 10140 |
Official gene symbol | | TOB1 |
Full name | | transducer of ERBB2, 1 |
Aliases | | ,APRO6,MGC104792,MGC34446,PIG49,TOB,TROB,TROB1, |
Gene summary | | This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q21 |
Gene position | | 48941413 - 48939584 Map Viewer |
Gene orientation | | minus |
Gene size | | 1830 bp |
Gene sequence |
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OMIM ID | | 605523 |
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