Entrez gene ID | | 10188 |
Official gene symbol | | TNK2 |
Full name | | tyrosine kinase, non-receptor, 2 |
Aliases | | ,ACK,ACK1,FLJ44758,FLJ45547,p21cdc42Hs, |
Gene summary | | This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3q29 |
Gene position | | 195635880 - 195590236 Map Viewer |
Gene orientation | | minus |
Gene size | | 45645 bp |
Gene sequence |
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OMIM ID | | 606994 |