Entrez gene ID | | 10232 |
Official gene symbol | | MSLN |
Full name | | mesothelin |
Aliases | | ,MPF,SMRP, |
Gene summary | | This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants. |
Location | | Chromosome: 16 Locus: 16p13.3 |
Gene position | | 810765 - 818865 Map Viewer |
Gene orientation | | plus |
Gene size | | 8101 bp |
Gene sequence |
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OMIM ID | | 601051 |
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