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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CDK8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1024
Official gene symbolCDK8
Full namecyclin-dependent kinase 8
Aliases,K35,MGC126074,MGC126075,
Gene summaryThe protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq]
LocationChromosome: 13   Locus: 13q12
Gene position26828756 - 26978569  Map Viewer
Gene orientationplus
Gene size149814 bp
Gene sequence
OMIM ID603184