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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PAK4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10298
Official gene symbolPAK4
Full namep21 protein (Cdc42/Rac)-activated kinase 4
Aliases,-,
Gene summaryPAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 19   Locus: 19q13.2
Gene position39616420 - 39670046  Map Viewer
Gene orientationplus
Gene size53627 bp
Gene sequence