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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MRVI1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10335
Official gene symbolMRVI1
Full namemurine retrovirus integration site 1 homolog
Aliases,IRAG,JAW1L,
Gene summaryThis gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p15
Gene position10715535 - 10594638  Map Viewer
Gene orientationminus
Gene size120898 bp
Gene sequence
OMIM ID604673