Entrez gene ID | | 10335 |
Official gene symbol | | MRVI1 |
Full name | | murine retrovirus integration site 1 homolog |
Aliases | | ,IRAG,JAW1L, |
Gene summary | | This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11p15 |
Gene position | | 10715535 - 10594638 Map Viewer |
Gene orientation | | minus |
Gene size | | 120898 bp |
Gene sequence |
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OMIM ID | | 604673 |
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