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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NOD1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10392
Official gene symbolNOD1
Full namenucleotide-binding oligomerization domain containing 1
Aliases,CARD4,CLR7.1,NLRC1,
Gene summaryThis gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq]
LocationChromosome: 7   Locus: 7p15-p14
Gene position30518393 - 30464143  Map Viewer
Gene orientationminus
Gene size54251 bp
Gene sequence
OMIM ID605980