| Entrez gene ID | | 10408 |
|
| Official gene symbol | | MYCNOS |
|
| Full name | | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) opposite strand |
|
| Aliases | | ,NCYM,NYCM, |
|
| Gene summary | | The N-myc oncogene has been implicated in the pathogenesis of a number of human tumors, including childhood neuroblastoma and adult small cell lung cancer. Complementary DNA clones derived from a transcription unit, N-cym, located on the opposite DNA strand to N-myc have been characterized. There is extensive overlap between the 5' ends of the two transcription units. The N-cym gene, which can encode a 109-amino acid protein, is expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels. Although other examples of overlapping, opposite-strand eukaryotic genes exist, N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid. This coregulation suggests that their protein products may be functionally interrelated during normal development and oncogenesis. [provided by RefSeq] |
|
| Location | | Chromosome: 2 Locus: 2p24.1 |
|
| Gene position | | 16081845 - 16080020 Map Viewer |
|
| Gene orientation | | minus |
|
| Gene size | | 1826 bp |
|
| Gene sequence |
| |
|
| OMIM ID | | 605374 |
|
|
|
