| Entrez gene ID | | 10497 |
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| Official gene symbol | | UNC13B |
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| Full name | | unc-13 homolog B (C. elegans) |
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| Aliases | | ,MGC133279,MGC133280,MUNC13,UNC13,Unc13h2,hmunc13, |
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| Gene summary | | This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq] |
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| Location | | Chromosome: 9 Locus: 9p12-p11 |
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| Gene position | | 35161989 - 35405332 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 243344 bp |
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| Gene sequence |
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| OMIM ID | | 605836 |
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