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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for IPO7 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10527
Official gene symbolIPO7
Full nameimportin 7
Aliases,FLJ14581,Imp7,MGC138673,RANBP7,
Gene summaryThe importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p15.4
Gene position9406169 - 9469674  Map Viewer
Gene orientationplus
Gene size63506 bp
Gene sequence
OMIM ID605586