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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RNASEH2A (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 10535 Official gene symbol RNASEH2A Full name ribonuclease H2, subunit A Aliases ,AGS4,JUNB,RNASEHI,RNHIA,RNHL, Gene summary The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid. Location Chromosome: 19   Locus: 19p13.2 Gene position 12917428 - 12924462  Map Viewer Gene orientation plus Gene size 7035 bp Gene sequence >RNASEH2A:4180230..4187264:Length=7035 GCGCCGAGACCCGCTCCTGCAGTATTAGTTCTTGCAGCTGGTGGTGGCGGCTGAGGCGGC ATGGATCTCAGCGAGCTGGAGAGAGACAATACAGGCCGCTGTCGCCTGAGTTCGCCTGTG CCCGCGGTGTGCCGCAAGGAGCCTTGCGTCCTGGGCGTCGATGAGGCGGGCAGGGGCCCC GTGCTGGGTGCGCCCCTAGGGCCAGGGAGGGGAGGGGCGTGGTACGGAGGATGCGGGAAA CGGGAGTCGGGATTGCACTGCACCAAGGGAGGGGATGTGGTCGTGGTGATGGCACCTAAA GAAGCAGTGATGATAGAACAGGGATGAATGGCAACTTTCACGGGCTCAGTGATTGGACCC CGGCTGCCAGAAAACTGACACCCCTTCTCCCCAGGCCCCATGGTCTACGCCATCTGTTAT TGTCCCCTGCCTCGCCTGGCAGATCTGGAGGCGCTGAAAGTGGCAGGTGAGCCCGAGGTG TGCGTCTGGGGAAGGGATTCCTGGGTATGTGCAGGGGCAGGTGAGAACTGAAAGGGGAGG GCAGGAACTGGGAGAACCAGCTGTTCCCCTTCTCTTCCAAACCTCCTCCCAGACTCAAAG ACCCTATTGGAGAGCGAGCGGGAAAGGCTGTTTGCGAAAATGGAGGACACGGACTTTGTC GGCTGGGCGCTGGATGTGCTGTCTCCAAACCTCATCTCTACCAGCATGCTTGGGCGGTGA GGGGTCCCCGGGAGGGGCAGCCAGCATGGGCTGACCAAGCTTTGTTCCTAGAATGAGATT AACTGGGCTCTGTTCCCCACCACAGGGTCAAATACAACCTGAACTCCCTGTCACATGATA CAGCCACTGGGCTTATACAGTATGCATTGGACCAGGGCGTGAACGTCACCCAGGTGAGTT AACTGTAAGTTGTCCCCATTTGGTCATCTCAGGATAAAATGGGGACAAAACAGGAGTTCG AGACTGCAGTGAGCCATGATCATGCCACAGCACTCCATCCTGGGTGACAAAGGAAGCCCC CCAACTCAAAAATGGAGGCAGGGCGCAGTGGCTCACGCCTATAATCGCAGCACTTTGGGA AGCCGCGGCGGGTAGATCACCGGAGGTCAAGAGTTCGAGACCAGCCTGACCAACATGGTG AAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGACGTGGTGGCAGGCGCCTGTAAT CCTAGCTACTCAGGAGGCTGAGACAGGAGAATCGCTTGAACCCAGGAGGCAGAAGTTGCA GTGAGCCAAGATTGTGCCATTGCACTCCAACCCGGGCAACAGAGCAAGACCCTGTCTCAA AAAAATAAAAAATAAAAAATAAACTAAAAATGGGAGACCAGGCGCAGTGGCTCACGGCTG TAATCCCAGCGTTTCAGGAGGCTGAGGCAGGCAGATCACCTGAGGTCAGGAGTTGAAGAC CATCCTGGCCAACATGGTGAAACCTCATCTCTACTGAAAATACAAAAAATTAGCCCAGCA TGGTGGCGGGTGCCTGTAATCCCACCTATTGGTGAGGCCGAGGCAGAAGAATTGCTCGAA CCCGGGAGGCGGAGGTTGCAGTGAGGTGAGATCGCGCCATTGCACTCCAGCCTGGGGGAC AGAGCGAAAAATAAAAATAAAAATAAAATAAAAAATAAATGTGGGCAAAAATGTGCAGTG TGCAGATTCAGCATCAGATACGTCTGGAGTGCCTCGGGCATATTCATTGCTACTGTTGAT TTCGTGCTCCTGTTTCTGCCCTAAATGTGTGCCACACTGACGACCACAGTGTAGCCCCTA GTCCCGTCTCCATCTAATCTCTCCCTCATCCTAAAGGCTCAGTCTCCAGAACAAATCCTA CATTGTCTACCTGTCACCTCTGTCCTAGCCCAGGACACCCCCCACTCCCTGGACACCTGC TGAGTGTCGTCTCTCGTCCCTCACCCTCCTATCCCCTCCAATCTGTTCCCCAAGCAGCAA CAGAAGGTAGTCTTTTTGAAATGCACATCTCGACATTTAGTTTTCCGATCACAGTGGAAA TTAAATCAGGAAAATTCACAGTCGAGTGGGGCAGAATTACATTAAATTACCAGAGAAAAA CATAAATCAGCATTGCCTCGAATGCTCTCAATGAAAGAATGGACCGTTCTGAGAGAATAA CAAGGCAAAATAACCTTGACGTAGGAATTGTATGCTGGGTATGGTGGCTCACGCCTGTAA TCCCAGCACTTTGGGAAGCTGAGGTGAGCAAATTGGTTGAGGCTAGGAGTTCCAGACCAG CCTGGGCAACATAGCGAGACTCCATCTCCACAAAAAGAAGAAGAAAGAAAGGAATTATAG CAAGGTAGACCCTGCTGAGGAGGGACCTGAGGACCAGGCCCAAATGCAGAGCTGGCGATA CAGTAACTGGTGTAGACAGACAAGGGCCCTACCCGTAGGCGTTCAGGGCCTAGCCTGGGC AGAAAGATGGTCAGCTGGAGGTTGGGCGCAGTAGCTCACGCCTGTAATCCCAGCACTTTG GGAGGCCGAGGCGGGCGGATCATCAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGT GAAACCCCATCTCTACTAAAAATAAAAAATAAAAAAATAAAACATGAAAGATGGTCAGCT GGTAAACAAAAAATAAAGGTTGTTTCTGAAAACAGTAGTGCTGTGGAGATACCACTTTCT CCCAGCAGCTCTTGGACCCTCTCTTCGGTGCTGCAGCCAAAGGCCCCCATGCATGGGCCC AGCATCATGAACCTGGTCCCAGCTCAGGGCCTTTGTACTGGCTGTTCTCACACCTAGAGC CCTCTTCCCCAGATCTCTGCACAGTTCACTTCCTCACCTCCTTCAAGCCTTTATTCACCA CTACACCTAGCTAACTTTTTATTTTTTGTAGAAACAGGGTCTCCATATGTTGCCCAGGTT GGTCTCAACCACCTGCCCTCAAGCGATCCTCCCACTTCGGCTTCCTAAAGTGTTGGGATT ACAGGCTTGTGCTAACGCACTCTACCAATTTTTTTCTAGTGTTTTCTGCCACCTCAGTTC CTAGAACAGTATGTGGCATGCAGTAGGTGCTAAATAAGTTAGAGTAAAAGCAGCGTGATA GAGAAAGCCTCTTCAGGAGGTGAGTTTTTTCTTTATTTTATTGTATTTATTTTATGTTTT TATAAAGATGGGGTCTCACTGTGTTGCCAAGCCTGGCCTCAAACTCCCAGGATCAAGCGA TCCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATCACAGGCCTGAACAACTTTGCCTGGTC TAGGAGGAGATGTTCGAGTTGAAATCCCTGATTGATCCATCCTGGGGACGTGCTGGAGAA GAGGATTCTGGGTAGCAGGAAGAACGTGCCAGGGCTGTGAGGCTAGAGCATTGGTACAGT TGTTTGTTCAATTAATATGTGTCTGTTGCTGTGGCAGGTATTCGTGGACACCGTAGGGAT GCCAGAGACATACCAGGCGCGGCTGCAGCAAAGTTTTCCCGGGATTGAGGTGACGGTCAA GGCCAAAGCAGATGCCCTCTACCCGGTGGTTAGTGCTGCCAGCATCTGTGCCAAGGTCAG TACCCTACTAGCCATGGCTGGCTTCCACCATCCCACTATATAGGGGCCAGGCATGGCCAC CAAAGGGAAGGAGGGAGATTCCAGGTGCCTGTTTTGCCCACAGGTGGCCCGGGACCAGGC CGTGAAGAAATGGCAGTTCGTGGAGAAACTGCAGGACTTGGATACTGATTATGGCTCAGG CTACCCCAATGGTGAGCAGACACGTGACCATGGTACTAATGTTGAAATGGCCAGGGCTGA GCACACTTCTGAGGTTTTCTTTTTTTCCTTTCTGTCATTTATCATTTTATTTTGCTTATT TTTTGTTTTTATTTGTTATTTTTGTTTATTTTTTGAGACGGAGTTTCGCTCTTTTTGCCC AGGCTGGAGTGTAATGGTGCGATCTCGGCTCACCGCAACCTCCACCTCCTGGCTTCAAGC GATTCTCCTGCCTCAGCCTCGCGAGTAGCTGGGATTACAGGCATGTGCCACCACACCCAG CTAATTTTGTGTTTTTAGTAGAGACTAGTTTTCTCCATGTTGGTCAGGCTGGTCTTGAAC TCCTGACCTCAGGTGATCTGCCTGGCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGA GCCACCGTGCCCAGCCTATTTTTTGTTTTTATAGAGATGGGGTCTTGTCATGTTGCCCAG GCTGGTCTCAAATTCCTGGAGTCAAGCAGTCCTCCCACCTTGGTCTTTCAAAGTGCTGGG ATTACAGCCATGAGCCACCACCCCTGGCCCTTTTTTTCTTCTTTTTTTAAAGAGATGGGG TCTCCCTATGTTGCCCAGCCTGGTCTTGAATTCCTGGGCTTAAGTGATCCTCCTGCCTTG GACTCCCAAATAGCTAGGATTACAGGTGTGAACTACTGTGCCTGGCTGGAGGTTTTCTAA ATTGCTCTGGTCACCCTACTCCACAGTGAAAGAGGCCAAGTGTTAGACAGTGGTGCCATT TGTTTATGGCCACACAGCCAGTGAGTGATAGAGCTGAATTCCAGGCCATAGGATTGCTGC TGTCTTCCCCGCTTCCCACTTTGCTGTCTTTCTGGAGCCCCAGTGATGGACTGAGACCCA AGGTGGGCATTTGTCCCTTTGTTAAGGGGAAGGGGACCAGGCGTGGTGGCTCATGCCTGT AATCCCAGCACTTTGGGAAGCTGAGGTAGGAGAACCGCTTGAGTCCTCGAGTTCAAGACC AGCCTGGGCAACATAGCGAGACCCCCATCTCTATAAAAAATTTAAAAAATTAGCCGGTTA TAGTGGTGCCCACCTGTAGTCCCAGCTACTCTGGAGGAGGAGGCTAAGGTGGGTGGGTTG CTTGAGCCCAGGAGTTGGAGGCTGCAGTGAGCTATGATTATGCCACTGCACTCCAGCCTT GGTGACAAGATGAGATCTTGTGTCAAAAAAAAAAATAATGTTAGCCAGGCGTGGTGGCTC ACACCTGTAATCCCAGGACTTTGGGAGGCTGAGGCAGGTGGATCCTTTGAGGTCAGGAGT TCTAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGCT GGACGTGGTGGCACACGCCCGTAATCCCAGCAACTCGGGAGGCTGAGGCAGGAGAATTAC TTAAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGCATAATTGCACTCCAGCCTGG GAAATGAGCAAAATTCCATCTCAAAATAATAATAATAATAATAATAATAATATTTAATGA CAGGCTGGGCCAGGTGGCTCATGCCCGTAATCCTAGCATTTTAAGAGACAGAGGCAGGTA GATCATGTGAACTCAGGAATTCACAACCAGCCTGGGCAATATGACAAGACCCCATCTCTA CAAAAAATACAAAAATTAGGTGTGGTGGTGCGCACCTGTAGTCCCAGCTACTTGGGAGGC TGAGGTGAGAGGATGGCTTGAGCCTGGGAGGCAGAGGTTGCATTGAGCTGTGATAATGTC ACTGCACTCCAGCCTGGGTAATAGAGCGAGACCCTATCTCAAAAAAATAAAAAGGCTGGG TGTGGTGTTTACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGA GGTCAGGAGTTTGAGACCAGCCTGCCTGTCCAATATGGTGAAACCCCGTCTCTACTAAAA ATACAAAAATTAGCCAGGTATGGTGGTGGGTGGCTGTAGTCCCAGCTACTTGGGAGGCTG AGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCAT TGCACTACAGCCTGGGTGACAGAGCAAGACTCCATTTCAAAAAATAAGTAAATAAAATAA AAATGTTTAATGACTTGTTCTTGGAGGTCAAGGAGATGTCTCAGAGGCAGTCTCCCTGCA CTGCCCTTTTAGCAGCTCTTGGCCAGGTAAAGGTCCTGTGGCAAGAAGGTGCTTCAGACC ATAGGAGGTGCCCCAGGTACTCAGGAGGAAGCCTTAGAAGAGCGGCAAGGAGGCCGGGCG TGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGGGGGTAGATCACGAGGT CAAGCAATTGAGACCATCCTGGCCAACATGGTGAAACCTCGTCACTACTAAAAACACAAA ATTTAGCTGGGCATGGTGGCATGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGG AGAATCGCTTGAATCCGGGAGGTGGAGGTTGCAGTGAGCTGAGATCGCGCCACTGCACTC CAGCCTGGCTACAGAGTGGGACTCCATCTCAAAGAAAAAAAAAAGAGTGGCAGGGAGCTT GAATGTTATGGTGCAACTTGGACTGTCACCATTGCCCACCCTACCCCAGATCCCAAGACA AAAGCGTGGTTGAAGGAGCACGTGGAGCCTGTGTTCGGCTTCCCCCAGTTTGTCCGGTTC AGCTGGCGCACGGCCCAGACCATCCTGGAGAAAGAGGCGGAAGATGTTATATGGTGGGTG TCATGGATGTCCTGGGGGTGCTATAGGGAAGGAAGGAGGGAGGCCAGCGTTCAGCCCTGC CTGAGAGGGTTGCTCCCTGTGTAAGTGGTCACTGTCATCACCTCTCTCCCACAGGGAGGA CTCAGCATCCGAGAATCAGGAGGGACTCAGGAAGATCACATCCTACTTCCTCAATGAAGG GTCCCAAGCCCGTCCCCGTTCTTCCCACCGATATTTCCTGGAACGCGGCCTGGAGTCAGC AACCAGCCTCTAGCAGCTGCCTCTACGCGCTCTACCTGCTTCCCCAACCCAGACATTAAA ATTGTTTAAGGAGAACCACACGTAGGGGATGTACTTTTGGGACAGAAGCAAGGTGGGAGT GTGCTCTGCAGCCGGGTCCAGCTACTTCCTTTTGGAACCTTAAATAGAATGGGTGTTGGT TGATTAATTTTATTT OMIM ID 606034