Entrez gene ID | | 10565 |
Official gene symbol | | ARFGEF1 |
Full name | | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) |
Aliases | | ,ARFGEP1,BIG1,D730028O18Rik,DKFZP434L057,P200, |
Gene summary | | ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition. [provided by RefSeq] |
Location | | Chromosome: 8 Locus: 8q13 |
Gene position | | 68255912 - 68109897 Map Viewer |
Gene orientation | | minus |
Gene size | | 146016 bp |
Gene sequence |
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OMIM ID | | 604141 |