| Entrez gene ID | | 10589 |
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| Official gene symbol | | DRAP1 |
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| Full name | | DR1-associated protein 1 (negative cofactor 2 alpha) |
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| Aliases | | ,NC2-alpha, |
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| Gene summary | | Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq] |
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| Location | | Chromosome: 11 Locus: 11q13.3 |
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| Gene position | | 65686728 - 65689048 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 2321 bp |
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| Gene sequence |
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| OMIM ID | | 602289 |
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