Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TRAF3IP2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10758
Official gene symbolTRAF3IP2
Full nameTRAF3 interacting protein 2
Aliases,ACT1,C6orf2,C6orf4,C6orf5,C6orf6,CIKS,DKFZp586G0522,MGC3581,
Gene summaryThis gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq]
LocationChromosome: 6   Locus: 6q21
Gene position111927474 - 111880143  Map Viewer
Gene orientationminus
Gene size47332 bp
Gene sequence
OMIM ID607043