Entrez gene ID | | 10758 |
Official gene symbol | | TRAF3IP2 |
Full name | | TRAF3 interacting protein 2 |
Aliases | | ,ACT1,C6orf2,C6orf4,C6orf5,C6orf6,CIKS,DKFZp586G0522,MGC3581, |
Gene summary | | This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6q21 |
Gene position | | 111927474 - 111880143 Map Viewer |
Gene orientation | | minus |
Gene size | | 47332 bp |
Gene sequence |
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OMIM ID | | 607043 |
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